Biomedical Nano-Engineering Laboratory

OU stephenson-biomedical-engineeringThe Wilhelm Lab is affiliated with the Stephenson School of Biomedical Engineering (SBME) at the University of Oklahoma (OU).

Our lab space is in Gallogly Hall at the OU Norman Campus.

Our research interests include engineering and design of nanomaterials for use in biomedical applications and clinical translation.


Publication in Journal of Biomedical Materials Research Part A

August 2021 – Nathan Donahue published a co-authored research article in the Journal of Biomedical Materials Research Part A. The work is a collaboration led by Dr. Emi Kiyotake and Prof. Michael Detamore (SBME).

E.A. Kiyotake, E.E. Thomas, H.B. Homburg, C.K. Milton, A.D. Smitherman, N.D. Donahue, K. Fung, S. Wilhelm, M.D. Martin, M.S. Detamore, “Conductive and injectable hyaluronic acid/gelatin/gold nanorod hydrogels for enhanced surgical translation and bioprinting.”
Journal of Biomedical Materials Research Part A, 2021, accepted.
DOI:10.1002/jbm.a.37294 | PDF (2.8 MB)

Wilhelm Lab Team 2021

June 2021 – Proudly presenting the Wilhelm lab team members. An amazing group of young scientists and engineers.

PC: Travis Caperton.


OU VPRP Strategic Equipment Investment Award

May 2021 – Our collaborative team of OU and OUHSC researchers received the 2021 OU VPRP Strategic Equipment Investment Award. Congratulations to the team and thanks to the OU VPRP Office for the funding!

Academic Year 2020/2021 Student Awards

April 2021 – Congratulations to our students who received the following awards:

  • Nathan Donahue: (i) Outstanding Graduate Research Assistant (OU Graduate Student Senate), and (ii) Outstanding Paper Award (OU SBME).
  • Evan Mettenbrink: Outstanding Research Award (OU SBME).
  • Emmy Francek: 2021 OU Regents’ Award for Outstanding Junior, and Tau Beta Pi Engineering Honor Society Scholarship.


Publication in Annual Review of Pharmacology and Toxicology

January 2021 – Wen Yang, Lin Wang, and Evan Mettenbrink published a review article in the journal Annual Review of Pharmacology and Toxicology in collaboration with Prof. Paul DeAngelis (OUHSC).

W. Yang, L. Wang, E. Mettenbrink, P. L. DeAngelis, S. Wilhelm, “Nanoparticle toxicology.“
Annual Review of Pharmacology and Toxicology, 2021, 61, 269-289.

DOI: 10.1146/annurev-pharmtox-032320-110338 | PDF (1.9 MB)

BE4NANO – Virtual Classroom Visit – Caddo-Kiowa Technology Center in Fort Cobb

December 2020 – As part of the “Bionanotechnology Engagement for Native Americans in Oklahoma” (BE4NANO) outreach and education initiative, Wilhelm Lab visited the Caddo-Kiowa Technology Center in Fort Cobb virtually via Zoom due to COVID19 restrictions to engage high school juniors in classroom hands-on demonstrations around bionanotechnology.

YouTube video from the Caddo-Kiowa Technology Center highlighting the BE4NANO outreach event:

Faculty Investment Program Award 2020

December 2020 – Wilhelm Lab received the Faculty Investment Program Award 2020 from the OU Vice President of Research and Partnerships.

Invited Presentations

November 2020 – Stefan Wilhelm delivered invited virtual talks at the University of Tennessee, Knoxville, Department of Chemical and Biomolecular Engineering, and the University of Minnesota, Minnesota Nano Center, Nanomedicine Workshop. Thank you for the invitations!

Publication in Advanced Functional Materials

November 2020 – Vinit Sheth and Lin Wang published an article in the journal Advanced Functional Materials in collaboration with Drs. Priyabrata Mukherjee and Resham Bhattacharya.

V. Sheth, L. Wang, R. Bhattacharya, P. Mukherjee, S. Wilhelm, “Strategies for delivering nanoparticles across tumor blood vessels.”
Advanced Functional Materials, 2020, published online.

DOI: 10.1002/adfm.20200736PDF (2.7 MB)

Publication in Bioactive Materials

September 2020 – Emmy Francek and Stefan Wilhelm co-authored a research article in the journal Bioactive Materials.

Y. Zhang, C.K. Elechalawar, M.N. Hossen, E.R. Francek, A. Dey, S. Wilhelm, R. Bhattacharya, P. Mukherjee, “Gold nanoparticles inhibit activation of cancer-associated fibroblasts by disrupting communication from tumor and microenvironmental cells.”
Bioactive Materials, 2021, 6, 326-332.

DOI:10.1016/j.bioactmat.2020.08.009  | PDF (0.6 MB)

OCAST Health Research Award 2020

August 2020 – Wilhelm Lab received the OCAST Health Research Award 2020.

Analytical and Bioanalytical Chemistry Cover – September 2020 Issue

August 2020 – “Assessing nanoparticle colloidal stability with Single-Particle Inductively Coupled Plasma Mass Spectrometry (SP-ICP-MS)” by Donahue et al. is highlighted on the September 2020 journal cover of Analytical and Bioanalytical Chemistry.

N. D. Donahue, E. R. Francek, E. Kiyotake, E. E. Thomas, W. Yang, L. Wang, M. S. Detamore, S. Wilhelm, “Assessing nanoparticle colloidal stability with Single-Particle Inductively Coupled Plasma Mass Spectrometry (SP-ICP-MS)”
Analytical and Bioanalytical Chemistry, 2020, 412, 5205-5216.

DOI: 10.1007/s00216-020-02783-6 | PDF (2.1 MB)

Outstanding Sophomore Award to Emmy Francek

July 2020 – Emmy Francek received the SBME Oustanding Sophomore Award 2020.