Biomedical Nano-Engineering Laboratory

The Wilhelm Lab is affiliated with the Stephenson School of Biomedical Engineering (SBME) at the University of Oklahoma (OU).

OU stephenson-biomedical-engineering




Our lab space is in Gallogly Hall at the OU Norman Campus.

Our research interests include the engineering and designing of nanomaterials for use in biomedical applications and clinical translation.



Publication in ACS Nano

April 2023 – Vinit Sheth and the team published an original research article in the journal ACS Nano.

V. Sheth, X. Chen, E. M. Mettenbrink, W. Yang, M. A. Jones, O. M’Saad, A. G. Thomas, R. S. Newport, E. R. Francek, L. Wang, A. N. Frickenstein, N. D. Donahue, A. M. Holden, N. Mjema, D. E. Green, P. L. DeAngelis, J. Bewersdorf, S. Wilhelm, “Quantifying intracellular nanoparticle distributions with three-dimensional super-resolution microscopy”
ACS Nano, 2023, published online.
DOI: 10.1021/acsnano.2c12808 | PDF (3.4 MB)

Inaugural Wilhelm Lab Olympics

April 2023 – The winners of the inaugural Wilhelm Lab Olympics are: Lin, Thao, Zephan, Sarah, Majood, and Vinit, aka “Team Vinit”. Thank you to our lab’s party planning committee for organizing!

Wayne Steen Award – Tekena Harcourt

April 2023 – Tekena Harcourt received the Wayne Steen Award for his exceptional leadership as a Diversity & Inclusion Scholar. Congratulations, Tekena!!

SBME Awards AY 2022/2023

April 2023 – Four Wilhelm Lab students were recognized with OU SBME awards in AY 2022/2023:

  • Amberlynn Demko – Outstanding Sophomore
  • Emmy Francek & Majood Haddad – Outstanding Graduate Teaching Assistants
  • Dr. Wen Yang – Outstanding PhD Graduate

Congratulations to all SBME award winners!


April 2023 – We participated in the 2023 National American Indian Science and Engineering Fair (NAISEF) in Stillwater at OK State University.

BE4NANO Day – March 2023

March 2023 – We hosted high school students from the Caddo-Kiowa Technology Center for our BE4NANO Day. Thanks to the OU SRNML, SBME, and GCoE outreach teams for the support!

Caddo-Kiowa Technology Center – STEM Day

March 2023 – We participated in the Caddo-Kiowa Technology Center STEM Day together with 150 high school students. Thanks to the Gallogly College of Engineering outreach team, the Stephenson School of Biomedical Engineering, and Prof. Rebecca Scott for the support.


March 2023 – Wilhelm Lab undergraduate student Rylee Newport received the NSF GRFP award! Outstanding accomplishment, Rylee!

Publication in Nature Materials

March 2023 – Lin Wang published a News & Views article in the journal Nature Materials.

L. Wang, S. Wilhelm, “Exploiting endothelial transcytosis to reach into the brain”
Nature Materials, 2023, 22, 282-283

DOI: 10.1038/s41563-023-01487-3 | PDF (2.8 MB)

Gallogly College of Engineering Teaching Award

February 2023 – Stefan received the Gallogly College of Engineering Teaching Scholar Award. Thank you to all students and colleagues for your support!


Publication in Analytical and Bioanalytical Chemistry

January 2023 – Alex Frickenstein, Shirsha Mukherjee, and the team published a research article in the journal Analytical and Bioanalytical Chemistry.

A. N. Frickenstein, S. Mukherjee, T. Harcourt, Y. He, V. Sheth, L. Wang, Z. Malik, S. Wilhelm, “Quantification of monodisperse and biocompatible gold nanoparticles by single-particle ICP-MS”
Analytical and Bioanalytical Chemistry, 2023, accepted.

DOI: 10.1007/s00216-023-04540-x | PDF (5.3 MB)

Publication in Micro

January 2023 – Nathan, Ellen, Vinit, and Emmy published a research article in Micro.

N. D. Donahue, E. Vance, V. Sheth, E. Francek, S. Wilhelm, “Synthesis, characterization, and acute cytotoxicity evaluation of chloroquine encapsulating liposomes”
Micro, 2023, 3, 1, 51-59.
DOI: 10.3390/micro3010005 | PDF (1.3 MB)

BE4NANO Classroom Visits 2022

November 2022 – Our SBME faculty team visited the pre-engineering and biomedical sciences high school classrooms at the Caddo-Kiowa Technology Center in Fort Cobb to engage students in bionanotechnology, bioimaging, and biomedical engineering.


Tekena Harcourt Received Pursuit of Excellence Award

October 2022 – Tekena, a current BME junior in the Wilhelm Lab, received the Gallogly College of Engineering Pursuit of Excellence Award. Congratulations Tekena!

Publication in Advanced Science

September 2022 – Vinit is a co-author of a collaborative research project led by Prof. Mukherjee (OUHSC). The paper has been published in  Advanced Science.

M.N. Hossen, L.Wang, S.K.D. Dwivedi, Y. Zhang, G. Rao, C.K. Elechalwar, V. Sheth, A. Dey, S. Asfa, S.K. Gulla, C. Xu, K. Fung, J.D. Robertson, M. Bieniasz, S. Wilhelm, R. Bhattacharya, P. Mukherjee, “Gold nanoparticles disrupt the IGFBP2/mTOR/PTEN axis to inhibit ovarian cancer growth”
Advanced Science, 2022, published.
DOI: 10.1002/advs.202200491  | PDF (11.1 MB)

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