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WILHELM LAB

Biomedical Nano-Engineering Laboratory

OU stephenson-biomedical-engineeringThe Wilhelm Lab is affiliated with the Stephenson School of Biomedical Engineering (SBME) at the University of Oklahoma (OU).

Our lab space is in Gallogly Hall at the OU Norman Campus.

Our research interests include engineering and design of nanomaterials for use in biomedical applications and clinical translation.


WILHELM LAB NEWS

Publication in Biosensors

April 2022 – Wen Yang published a co-first author paper in the journal Biosensors with colleagues from OU, Iowa State University, and Tufts University. The project was led by Drs. Binbin Weng and Qing He.

LABEL-FREE DIFFERENTIATION OF CANCER AND NON-CANCER CELLS BASED ON MACHINE-LEARNING-ALGORITHM-ASSISTED FAST RAMAN IMAGING
Q. He*, W. Yang*, W. Luo, S. Wilhelm, B. Weng, “Label-free differentiation of cancer and non-cancer cells based on machine-learning-algorithm-assisted fast raman imaging”
Biosensors, 2022, 12, 250.

DOI: 10.3390/bios12040250PDF (2.3 MB)

Publication in International Journal of Molecular Sciences

April 2022 – We published a co-author paper in the International Journal of Molecular Sciences (IJMS) with colleagues from OUHSC. The project was led by Prof. James Battiste (Department of Neurosurgery and Stephenson Cancer Center, OUHSC).

PHYSICAL FORCES IN GLIOBLASTOMA MIGRATION: A SYSTEMATIC REVIEW
A. Grossen, K. Smith, N. Coulibaly, B. Arbuckle, A. Evans, S. Wilhelm, K. Jones, I. Dunn, R. Towner, D. Wu, Y.-T. Kim,  J. Battiste, “Physical forces in glioblastoma migration: a systematic review”
International Journal of Molecular Sciences, 2022, 23, 7, 4055.

DOI: 10.3390/ijms23074055 | PDF (1.3 MB)

NSF GRFP Award

April 2022 – Wilhelm Lab undergraduate student Alyssa Holden received the NSF GRFP award! Outstanding accomplishment, Alyssa!

BE4NANO Day 2022

March 2022 – High school students from the Caddo-Kiowa Technology Center in Fort Cobb visited our lab as part of the 2nd BE4NANO DAY to learn more about our bionanotechnology research, college admission, and the University of Oklahoma. Thank you to everyone involved for making this day a success!

Dissertation Excellence Award to Wen Yang

February 2022 – Our Wilhelm Lab Ph.D. candidate Wen Yang received the Gallogly College of Engineering Dissertation Excellence Award. Congratulations, Wen!

Webinar with PerkinElmer

February 2022 – Our recent Wilhelm Lab Ph.D. graduate Dr. Nathan Donahue presented a webinar in collaboration with PerkinElmer on his recent Nano Letters paper that demonstrates the development and application of dual-analyte single particle ICP-MS. Congratulations, Dr. Donahue!

Paper link:

QUANTIFYING CHEMICAL COMPOSITION AND REACTION KINETICS OF INDIVIDUAL COLLOIDALLY DISPERSED NANOPARTICLES
N.D. Donahue, S. Kanapilly, C. Stephan, M. Caleb Marlin, E.R. Francek, M. Haddad, J. Guthridge, S. Wilhelm “Quantifying chemical composition and reaction kinetics of individual colloidally dispersed nanoparticles.”
Nano Letters, 2022, 22, 1, 294–301.
DOI: 10.1021/acs.nanolett.1c03752 | PDF (4.2 MB)

Publication in Materials Today

February 2022 – Wen Yang and Alex Frickenstein co-authored a collaborative research article in the journal Materials Today. The study was led by Prof. Priyabrata Mukherjee at the OU Health Sciences Center/Stephenson Cancer Center.

Y. Zhang, C.K. Elechalawar, W. Yang, A. Frickenstein, S. Asfa, K.M. Fung, B. N. Murphy, S. K. Dwivedi, G. Rao, A. Dey, S. Wilhelm, R. Bhattacharya, P. Mukherjee, “Disabling partners in crime: Gold nanoparticles disrupt multicellular communications within the tumor microenvironment to inhibit ovarian tumor aggressiveness.”
Materials Today, 2022, published online.

DOI: 10.1016/j.mattod.2022.01.025  | PDF (9.9 MB)

Publication in Nano Letters

February 2022 – Wen Yang and her team of graduate, undergraduate, and high school students published a paper in Nano Letters in collaboration with colleagues from OUHSC.

NANOPARTICLE SURFACE ENGINEERING WITH HEPAROSAN POLYSACCHARIDE REDUCES SERUM PROTEIN ADSORPTION AND ENHANCES CELLULAR UPTAKE
W. Yang, L. Wang, M. Fang, V. Sheth, Y. Zhang, A. M. Holden, N. D. Donahue, D. E. Green, A. N. Frickenstein, E. M. Mettenbrink, T. A. Schwemley, E. R. Francek, M. Haddad, Md N. Hossen, S. Mukherjee, S. Wu, P. L. DeAngelis, S. Wilhelm, “Nanoparticle surface engineering with heparosan polysaccharide reduces serum protein adsorption and enhances cellular uptake”
Nano Letters, 2022, 22, 2, 2103-2111.
DOI: 10.1021/acs.nanolett.2c00349 | PDF (5.6 MB)

Publication in Nano Letters

December 2021 – Dr. Nathan Donahue, Emmy Francek, and Majood Haddad published a paper in Nano Letters in collaboration with colleagues from PerkinElmer and OMRF.

QUANTIFYING CHEMICAL COMPOSITION AND REACTION KINETICS OF INDIVIDUAL COLLOIDALLY DISPERSED NANOPARTICLES
N.D. Donahue, S. Kanapilly, C. Stephan, M. Caleb Marlin, E.R. Francek, M. Haddad, J. Guthridge, S. Wilhelm “Quantifying chemical composition and reaction kinetics of individual colloidally dispersed nanoparticles.”
Nano Letters, 2022, 22, 1, 294–301.
DOI: 10.1021/acs.nanolett.1c03752 | PDF (4.2 MB)

Ph.D. Defense – Nathan Donahue

December 2021 – Nathan Donahue defended his Ph.D. thesis with the title “Establishing elemental analysis to quantify nanoscale interactions at single nanoparticle and single cell levels”. Congratulations, Dr. Donahue! Thank you to the Ph.D. committee members, Drs. Handan Acar, Michael Detamore, and Luca Fornelli.

Outstanding Senior – Emmy Francek

November 2021 – Our undergraduate student, Emmy Francek, has been selected as the OU Gallogly College of Engineering Outstanding Senior. Congratulations, Emmy!

BE4NANO Outreach

October 2021 – As part of the “Bionanotechnology Engagement for Native Americans in Oklahoma” (BE4NANO) outreach and education initiative, Wilhelm Lab visited the Caddo-Kiowa Technology Center in Fort Cobb to engage high school juniors in classroom hands-on demonstrations around bionanotechnology. We thank SBME Prof. Rebecca Scott for joining us, and we are grateful for the support through the NSF CAREER award (2048130).

Publication in Journal of Biomedical Materials Research Part A

August 2021 – Nathan Donahue published a co-authored research article in the Journal of Biomedical Materials Research Part A. The work is a collaboration led by Dr. Emi Kiyotake and Prof. Michael Detamore (SBME).

CONDUCTIVE AND INJECTABLE HYALURONIC ACID/GELATIN/GOLD NANOROD HYDROGELS FOR ENHANCED SURGICAL TRANSLATION AND BIOPRINTING
E.A. Kiyotake, E.E. Thomas, H.B. Homburg, C.K. Milton, A.D. Smitherman, N.D. Donahue, K. Fung, S. Wilhelm, M.D. Martin, M.S. Detamore, “Conductive and injectable hyaluronic acid/gelatin/gold nanorod hydrogels for enhanced surgical translation and bioprinting.”
Journal of Biomedical Materials Research Part A, 2022, 110, 2, 365-382.
DOI:10.1002/jbm.a.37294 | PDF (2.8 MB)
Highlighted on journal cover page (Journal of Biomedical Materials Research Part A; Volume: 110; Issue: 2; February 2022)

Wilhelm Lab Team 2021

June 2021 – Proudly presenting the Wilhelm lab team members. An amazing group of young scientists and engineers.

PC: Travis Caperton.

 

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