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WILHELM LAB

Biomedical Nano-Engineering Laboratory

The Wilhelm Lab is affiliated with the Stephenson School of Biomedical Engineering (SBME) at the University of Oklahoma (OU).

OU stephenson-biomedical-engineering

 

 

 

Our lab space is in Gallogly Hall at the OU Norman Campus.

Our research interests include the engineering and designing of nanomaterials for use in biomedical applications and clinical translation.


 

WILHELM LAB NEWS

Publication in Advanced Science

September 2022 – Vinit is a co-author of a collaborative research project led by Prof. Mukherjee (OUHSC). The paper has been published in  Advanced Science.

GOLD NANOPARTICLES DISRUPT THE IGFBP2/MTOR/PTEN AXIS TO INHIBIT OVARIAN CANCER GROWTH
M.N. Hossen, L.Wang, S.K.D. Dwivedi, Y. Zhang, G. Rao, C.K. Elechalwar, V. Sheth, A. Dey, S. Asfa, S.K. Gulla, C. Xu, K. Fung, J.D. Robertson, M. Bieniasz, S. Wilhelm, R. Bhattacharya, P. Mukherjee, “Gold nanoparticles disrupt the IGFBP2/mTOR/PTEN axis to inhibit ovarian cancer growth”
Advanced Science, 2022, published.
DOI: 10.1002/advs.202200491  | PDF (11.1 MB)

Publication in Advanced Photonics Research

September 2022 – Evan Mettenbrink and Wen Yang published a review paper in Advanced Photonics Research.

BIOIMAGING WITH UPCONVERSION NANOPARTICLES
E. Mettenbrink, W. Yang, S. Wilhelm, “Bioimaging with upconversion nanoparticles”
Advanced Photonics Research, 2022, published.
DOI: 10.1002/adpr.202200098  | PDF (2.2 MB)

Publication in Nano Letters

September 2022 – Wen Yang and her team published a paper in Nano Letters in collaboration with colleagues from OUHSC.

CONTROLLING NANOPARTICLE UPTAKE IN INNATE IMMUNE CELLS WITH HEPAROSAN POLYSACCHARIDES
W. Yang, A. N. Frickenstein, A. M. Holden, V. Sheth, E. M. Mettenbrink, L. Wang, A. Woodward, B. Joo, S. Butterfield, N. D. Donahue, D. E. Green, A. Thomas, T. Harcourt, Y. Hamilton, M. Tang, Z. Malik, R. Harrison, P. Mukherjee, P. L. DeAngelis, S. Wilhelm, “Controlling nanoparticle uptake in innate immune cells with heparosan polysaccharides.”
Nano Letters, 2022, published.
DOI: 10.1021/acs.nanolett.2c02226  | PDF (6.5 MB)

Presbyterian Health Foundation Team Grant

July 2022 – Wilhelm Lab received funding support for a Team Grant from the Presbyterian Health Foundation.

Ph.D. Defense – Wen Yang

July 2022 – Wen Yang defended her Ph.D. thesis with the title “A novel polysaccharide-based surface engineering strategy for nanomedicines”. Congratulations, Dr. Yang! Thank you to the Ph.D. committee members, Drs. Handan Acar, Qinggong Tang, and Zhibo Yang.

Wilhelm Lab Team 2022

July 2022 – The Wilhelm Lab team members in Summer 2022. An amazing group of young scientists and engineers.

PC: Travis Caperton.

BE4NANO Summer Camp 2022

May 2022 – High school students from the Caddo-Kiowa Technology Center in Fort Cobb participated in a week-long summer research camp.

     

Publication in Nano Letters

May 2022 – Dr. Nathan Donahue and his team published a paper in Nano Letters in collaboration with colleagues from PerkinElmer.

ABSOLUTE QUANTIFICATION OF NANOPARTICLE INTERACTIONS WITH INDIVIDUAL HUMAN B CELLS BY SINGLE CELL MASS SPECTROMETRY
N. D. Donahue, V. Sheth, A. N. Frickenstein, A. Holden, S. Kanapilly, S. Chady, S. Wilhelm, “Absolute quantification of nanoparticle interactions with individual human b cells by single cell mass spectrometry”
Nano Letters, 2022, published online
DOI: 10.1021/acs.nanolett.2c01037 | PDF (2.5 MB)

BE4NANO Day 2022

April 2022 – High school students from the Caddo-Kiowa Technology Center in Fort Cobb visited the OU Gallogly College of Engineering and the OU Samuel Roberts Nobel Microscopy Laboratory as part of the 3rd BE4NANO DAY. Thank you to everyone involved for making this day a success, in particular Benjamin “BJ” Lee, the OU AISES student chapter, the GCoE Diversity, Equity, and Inclusion program (Lisa Morales), and the SRNML team (Andy Madden, Preston Larson, Julian Sabisch, and Tingting Gu).

Academic Year 2021/2022 Student Awards

April 2022 – Congratulations to our students who received the following awards:

  • Nathan Donahue: Outstanding PhD Graduate Student (OU SBME)
  • Evan Mettenbrink: Outstanding MS Graduate Student (OU SBME)
  • Emmy Francek: Outstanding Senior (OU SBME); Letzeiser Award (OU); Campus Life Award (OU); Outstanding Senior (GCoE)
  • Hamilton Young: Exemplary Sophomore (OU SBME)
  • Wen Yang: Best Research Paper (OU SBME)
  • Alex Frickenstein: Outstanding Teaching Assistant (OU SBME); SRNML Voucher Program Award (OU)
  • Alyssa Holden: NSF GRFP Award
  • Rylee Newport: Delta Gamma Scholarship (OU)

Publication in Biosensors

April 2022 – Wen Yang published a co-first author paper in the journal Biosensors with colleagues from OU, Iowa State University, and Tufts University. The project was led by Drs. Binbin Weng and Qing He.

LABEL-FREE DIFFERENTIATION OF CANCER AND NON-CANCER CELLS BASED ON MACHINE-LEARNING-ALGORITHM-ASSISTED FAST RAMAN IMAGING
Q. He*, W. Yang*, W. Luo, S. Wilhelm, B. Weng, “Label-free differentiation of cancer and non-cancer cells based on machine-learning-algorithm-assisted fast raman imaging”
Biosensors, 2022, 12, 250.

DOI: 10.3390/bios12040250PDF (2.3 MB)

Publication in International Journal of Molecular Sciences

April 2022 – We published a co-author paper in the International Journal of Molecular Sciences (IJMS) with colleagues from OUHSC. The project was led by Prof. James Battiste (Department of Neurosurgery and Stephenson Cancer Center, OUHSC).

PHYSICAL FORCES IN GLIOBLASTOMA MIGRATION: A SYSTEMATIC REVIEW
A. Grossen, K. Smith, N. Coulibaly, B. Arbuckle, A. Evans, S. Wilhelm, K. Jones, I. Dunn, R. Towner, D. Wu, Y.-T. Kim,  J. Battiste, “Physical forces in glioblastoma migration: a systematic review”
International Journal of Molecular Sciences, 2022, 23, 7, 4055.

DOI: 10.3390/ijms23074055 | PDF (1.3 MB)

NSF GRFP Award

April 2022 – Wilhelm Lab undergraduate student Alyssa Holden received the NSF GRFP award! Outstanding accomplishment, Alyssa!

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