May 2022 – High school students from the Caddo-Kiowa Technology Center in Fort Cobb participated in a week-long summer research camp.

May 2022 – Dr. Nathan Donahue and his team published a paper in Nano Letters in collaboration with colleagues from PerkinElmer.

ABSOLUTE QUANTIFICATION OF NANOPARTICLE INTERACTIONS WITH INDIVIDUAL HUMAN B CELLS BY SINGLE CELL MASS SPECTROMETRY
N. D. Donahue, V. Sheth, A. N. Frickenstein, A. Holden, S. Kanapilly, S. Chady, S. Wilhelm, “Absolute quantification of nanoparticle interactions with individual human b cells by single cell mass spectrometry”
Nano Letters, 2022, published online
DOI: 10.1021/acs.nanolett.2c01037 | PDF (2.5 MB)

April 2022 – High school students from the Caddo-Kiowa Technology Center in Fort Cobb visited the OU Gallogly College of Engineering and the OU Samuel Roberts Nobel Microscopy Laboratory as part of the 3rd BE4NANO DAY. Thank you to everyone involved for making this day a success, in particular Benjamin “BJ” Lee, the OU AISES student chapter, the GCoE Diversity, Equity, and Inclusion program (Lisa Morales), and the SRNML team (Andy Madden, Preston Larson, Julian Sabisch, and Tingting Gu).

April 2022 – Congratulations to our students who received the following awards:

• Nathan Donahue: Outstanding PhD Graduate Student (OU SBME)
• Evan Mettenbrink: Outstanding MS Graduate Student (OU SBME)
• Emmy Francek: Outstanding Senior (OU SBME); Letzeiser Award (OU); Campus Life Award (OU); Outstanding Senior (GCoE)
• Hamilton Young: Exemplary Sophomore (OU SBME)
• Wen Yang: Best Research Paper (OU SBME)
• Alex Frickenstein: Outstanding Teaching Assistant (OU SBME); SRNML Voucher Program Award (OU)
• Alyssa Holden: NSF GRFP Award
• Rylee Newport: Delta Gamma Scholarship (OU)

April 2022 – Wen Yang published a co-first author paper in the journal Biosensors with colleagues from OU, Iowa State University, and Tufts University. The project was led by Drs. Binbin Weng and Qing He.

LABEL-FREE DIFFERENTIATION OF CANCER AND NON-CANCER CELLS BASED ON MACHINE-LEARNING-ALGORITHM-ASSISTED FAST RAMAN IMAGING
Q. He*, W. Yang*, W. Luo, S. Wilhelm, B. Weng, “Label-free differentiation of cancer and non-cancer cells based on machine-learning-algorithm-assisted fast raman imaging”
Biosensors, 2022, 12, 250.

DOI: 10.3390/bios12040250 | PDF (2.3 MB)

April 2022 – We published a co-author paper in the International Journal of Molecular Sciences (IJMS) with colleagues from OUHSC. The project was led by Prof. James Battiste (Department of Neurosurgery and Stephenson Cancer Center, OUHSC).

PHYSICAL FORCES IN GLIOBLASTOMA MIGRATION: A SYSTEMATIC REVIEW
A. Grossen, K. Smith, N. Coulibaly, B. Arbuckle, A. Evans, S. Wilhelm, K. Jones, I. Dunn, R. Towner, D. Wu, Y.-T. Kim,  J. Battiste, “Physical forces in glioblastoma migration: a systematic review”
International Journal of Molecular Sciences, 2022, 23, 7, 4055.

DOI: 10.3390/ijms23074055 | PDF (1.3 MB)

April 2022 – Wilhelm Lab undergraduate student Alyssa Holden received the NSF GRFP award! Outstanding accomplishment, Alyssa!

March 2022 – Wilhelm Lab received funding support for a Junior-PI project through an NIH COBRE Award (PI: Dr. Bin Zheng). Congratulations to the team!

March 2022 – High school students from the Caddo-Kiowa Technology Center in Fort Cobb visited our lab as part of the 2nd BE4NANO DAY to learn more about our bionanotechnology research, college admission, and the University of Oklahoma. Thank you to everyone involved for making this day a success!

February 2022 – Our Wilhelm Lab Ph.D. candidate Wen Yang received the Gallogly College of Engineering Dissertation Excellence Award. Congratulations, Wen!

February 2022 – Our recent Wilhelm Lab Ph.D. graduate Dr. Nathan Donahue presented a webinar in collaboration with PerkinElmer on his recent Nano Letters paper that demonstrates the development and application of dual-analyte single particle ICP-MS. Congratulations, Dr. Donahue!

Paper link:

QUANTIFYING CHEMICAL COMPOSITION AND REACTION KINETICS OF INDIVIDUAL COLLOIDALLY DISPERSED NANOPARTICLES
N.D. Donahue, S. Kanapilly, C. Stephan, M. Caleb Marlin, E.R. Francek, M. Haddad, J. Guthridge, S. Wilhelm “Quantifying chemical composition and reaction kinetics of individual colloidally dispersed nanoparticles.”
Nano Letters, 2022, 22, 1, 294–301.
DOI: 10.1021/acs.nanolett.1c03752 | PDF (4.2 MB)

February 2022 – Wen Yang and Alex Frickenstein co-authored a collaborative research article in the journal Materials Today. The study was led by Prof. Priyabrata Mukherjee at the OU Health Sciences Center/Stephenson Cancer Center.

Y. Zhang, C.K. Elechalawar, W. Yang, A. Frickenstein, S. Asfa, K.M. Fung, B. N. Murphy, S. K. Dwivedi, G. Rao, A. Dey, S. Wilhelm, R. Bhattacharya, P. Mukherjee, “Disabling partners in crime: Gold nanoparticles disrupt multicellular communications within the tumor microenvironment to inhibit ovarian tumor aggressiveness.”
Materials Today, 2022, published online.

DOI: 10.1016/j.mattod.2022.01.025  | PDF (9.9 MB)

February 2022 – Wen Yang and her team of graduate, undergraduate, and high school students published a paper in Nano Letters in collaboration with colleagues from OUHSC.

NANOPARTICLE SURFACE ENGINEERING WITH HEPAROSAN POLYSACCHARIDE REDUCES SERUM PROTEIN ADSORPTION AND ENHANCES CELLULAR UPTAKE
W. Yang, L. Wang, M. Fang, V. Sheth, Y. Zhang, A. M. Holden, N. D. Donahue, D. E. Green, A. N. Frickenstein, E. M. Mettenbrink, T. A. Schwemley, E. R. Francek, M. Haddad, Md N. Hossen, S. Mukherjee, S. Wu, P. L. DeAngelis, S. Wilhelm, “Nanoparticle surface engineering with heparosan polysaccharide reduces serum protein adsorption and enhances cellular uptake”
Nano Letters, 2022, 22, 2, 2103-2111.
DOI: 10.1021/acs.nanolett.2c00349 | PDF (5.6 MB)

December 2021 – Dr. Nathan Donahue, Emmy Francek, and Majood Haddad published a paper in Nano Letters in collaboration with colleagues from PerkinElmer and OMRF.

QUANTIFYING CHEMICAL COMPOSITION AND REACTION KINETICS OF INDIVIDUAL COLLOIDALLY DISPERSED NANOPARTICLES
N.D. Donahue, S. Kanapilly, C. Stephan, M. Caleb Marlin, E.R. Francek, M. Haddad, J. Guthridge, S. Wilhelm “Quantifying chemical composition and reaction kinetics of individual colloidally dispersed nanoparticles.”
Nano Letters, 2022, 22, 1, 294–301.
DOI: 10.1021/acs.nanolett.1c03752 | PDF (4.2 MB)

December 2021 – Nathan Donahue defended his Ph.D. thesis with the title “Establishing elemental analysis to quantify nanoscale interactions at single nanoparticle and single cell levels”. Congratulations, Dr. Donahue! Thank you to the Ph.D. committee members, Drs. Handan Acar, Michael Detamore, and Luca Fornelli.